Helmut K Seitz Selected Research

Cytochrome P-450 CYP2E1 (CYP2E1)

1/2022	Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease.
1/2018	Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues.
10/2016	Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1.
12/2015	Detection of carcinogenic etheno-DNA adducts in children and adolescents with non-alcoholic steatohepatitis (NASH).
4/2015	The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease.
1/2015	Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1.
1/2014	The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.
1/2013	The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis.
12/2012	Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats.
2/2011	Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions.

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Helmut K Seitz Research Topics

Disease

18	Carcinogenesis 01/2020 - 01/2002
17	Neoplasms (Cancer) 01/2018 - 01/2005
11	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2022 - 01/2002
9	Inflammation (Inflammations) 01/2018 - 04/2006
8	Fibrosis (Cirrhosis) 01/2021 - 09/2003
6	Fatty Liver 01/2022 - 06/2004
6	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018 - 04/2008
6	Alcoholic Fatty Liver 01/2018 - 10/2010
6	Liver Diseases (Liver Disease) 12/2015 - 07/2005
5	Non-alcoholic Fatty Liver Disease 01/2017 - 11/2007
4	Obesity 01/2021 - 04/2006
4	Alcoholism (Alcohol Abuse) 01/2018 - 05/2005
4	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2017 - 01/2005
4	Hepatitis 05/2011 - 07/2003
3	Malnutrition (Nutritional Deficiencies) 01/2017 - 01/2005
3	Infections 09/2013 - 07/2009
2	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 01/2018 - 04/2008
2	Liver Cell Adenoma (Hepatocellular Adenoma) 12/2012 - 06/2011
2	Body Weight (Weight, Body) 06/2011 - 11/2002
2	Colorectal Neoplasms (Colorectal Cancer) 06/2010 - 03/2009
2	Hemochromatosis (Bronze Diabetes) 04/2008 - 06/2004
2	Chronic Pancreatitis 09/2007 - 10/2006
1	Rare Diseases (Rare Disease) 03/2022
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Drug-Related Side Effects and Adverse Reactions 01/2022
1	Prediabetic State (Prediabetes) 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Disease Progression 01/2018
1	Ascites 01/2018
1	Alcoholic Hepatitis 01/2017
1	Colonic Neoplasms (Colon Cancer) 06/2015
1	Acute Cholecystitis 09/2013
1	Hepatorenal Syndrome 06/2013
1	Jaundice (Icterus) 06/2013
1	Liver Failure 05/2011
1	Hyperhomocysteinemia 10/2010
1	Chronic Hepatitis (Chronic Active Hepatitis) 01/2010
1	Hepatocellular Carcinoma (Hepatoma) 01/2010

Drug/Important Bio-Agent (IBA)

23	Ethanol (Ethyl Alcohol)IBA 01/2018 - 01/2002
14	AcetaldehydeIBA 01/2018 - 02/2004
12	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2022 - 01/2002
8	EnzymesIBA 06/2013 - 01/2005
7	Biomarkers (Surrogate Marker)IBA 03/2022 - 05/2005
7	DNA AdductsIBA 01/2018 - 01/2009
6	Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA 01/2015 - 04/2006
5	CytochromesIBA 01/2020 - 01/2002
4	CytokinesIBA 01/2018 - 04/2008
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2013 - 02/2004
3	Chlormethiazole (Clomethiazole)IBA 01/2022 - 11/2002
3	RetinoidsIBA 12/2012 - 08/2007
3	Pharmaceutical PreparationsIBA 11/2007 - 01/2002
2	Biological ProductsIBA 01/2017 - 12/2014
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2015 - 01/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 10/2010
2	Proteins (Proteins, Gene)FDA Link 12/2012 - 07/2009
2	CarcinogensIBA 06/2011 - 01/2009
2	Vitamin A (Retinol)FDA LinkGeneric 05/2011 - 01/2002
2	IsoenzymesIBA 06/2010 - 06/2007
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 07/2009 - 04/2008
2	Transforming Growth Factor beta (TGF-beta)IBA 07/2009 - 04/2008
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2009 - 02/2004
2	aldehyde dehydrogenase (NAD(P)+) (acetaldehyde dehydrogenase)IBA 06/2007 - 01/2007
2	DNA (Deoxyribonucleic Acid)IBA 01/2007 - 02/2004
1	LipidsIBA 01/2022
1	Coffee FDA Link 01/2021
1	TeaIBA 01/2021
1	ChemokinesIBA 01/2018
1	BilirubinIBA 01/2018
1	Keratin-18 (Keratin 18)IBA 01/2017
1	N 30IBA 01/2017
1	CaspasesIBA 01/2017
1	Apoptosis Regulatory ProteinsIBA 10/2016
1	OsteopontinIBA 01/2015
1	MutagensIBA 01/2014
1	AdiponectinIBA 10/2013
1	Sirtuin 1IBA 10/2013
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2013
1	Moxifloxacin (Avelox)FDA Link 09/2013
1	Pentoxifylline (Trental)FDA LinkGeneric 06/2013
1	8-Hydroxy-2'-DeoxyguanosineIBA 12/2012
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 12/2012
1	Dihydrotachysterol (AT 10)IBA 06/2011
1	Insulin-Like Growth Factor I (IGF-1)IBA 06/2011
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2011
1	CannabinoidsIBA 01/2011
1	Messenger RNA (mRNA)IBA 01/2011
1	Dronabinol (THC)FDA LinkGeneric 01/2011
1	Thioacetamide (Thioacetamid)IBA 01/2011
1	RimonabantIBA 01/2011
1	Tissue Inhibitor of Metalloproteinase-1IBA 01/2011
1	EndotoxinsIBA 10/2010
1	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2010
1	CreatinineIBA 01/2010
1	HepcidinsIBA 07/2009

Therapy/Procedure

6	Therapeutics 01/2022 - 07/2005
6	Liver Transplantation 01/2018 - 07/2003
1	Cholecystectomy 09/2013
1	Conservative Treatment 09/2013
1	Laparoscopic Cholecystectomy 09/2013
1	Intraperitoneal Injections 12/2012